Dr James M Osborne 


In 20002004 I completed an undergraduate degree in Mathematics at New College. From there I went to the Life Sciences interface Doctoal Training Centre (LSI DTC) to begin my DPhil studies. For research component of my DPhil I was based in the Computational Biology Group under the supervision of Jonathan Whiteley, my thesis was entitled "Numerical and Computational Methods for Simulating Multiphase Models of Tissue Growth".
From 20082011 I was working as a Post Doctoral Research Asistant, in the Computational Biology Group, looking at "Computational Approaches to Multiscale Modelling in Systems Biology" as part of the Oxford Centre for Integrative Systems Biology (OCISB). Between 2009 ans 2013 I returned to the DTC (www.dtc.ox.ac.uk) as an Associate Director with my time split betwen research and the DTC.
From 2011  2014 I was a Senior Researcher in the Computational Biology Group and lead the cell based modeling group.
For 2013 and 2014 I was seconded to Microsoft Research Cambridge as part of the Boiological Computation Group in the Computational Science Laboratory.
Since January 2015 I have been a Lecturer in applied mathematics at the University of Melbourne.
My expertise is in numerical and computational methods for mathematical models of biological phenomena. I have experience
in the formation and simulation of continuum, discrete and hybrid modes using techniques from both applied mathematics and
numerical analysis.
My current Interests are in the development of robust mathematical and numerical methods for
multiscale modeling in systems biology. Key areas of interest are
The main aspect of this work is developing the cellbased component of the Chaste project (www.cs.ox.ac.uk/chaste), a key question here is, which model is appropriate? The following movies show a comparison between a cell centre based simulation and a cell vertex based simulation, and the effect of varying cell properties in the models.
Left: a crypt, represented by a cellcentre model (left) and a cellvertex model (right). Right: a crypt represented by a cellcentre model with a population of mutant cells shown in black, the simulation on the right represents mutant cells with increased adhesivenes.
Chaste can be used to simulate interacting populations of cells in 2D and 3D.
Left: monoclonal conversion in a healthy crypt in a three dimensional fixed geometry. Right: demo of a simulation with multiple crypts.
See www.cs.ox.ac.uk/chaste for more information.
Another of my research interests is the area of numerical and computational methods for multiphase models of tissue growth. Involving the application of the finite element method to coupled and constrained partial differential equations. For my doctoral thesis I developed a numerical and computational framework based upon the galerkin finite element method that allows the numerical solution of coupled systems of parabolic, elliptic and hyperbolic PDEs resulting from multiphase models of tissue growth. the modelling approach is to consider the tissue to be composed of separate constitutive phases, which are each governed by suitable continuum physical laws. This enables investigation of the effect of interactions between constitutive phases on the growth of the tissue. The framework has been used to investigate tissue growth in a perfusion bioreactor and also the development of a solid tumour, under nonuniform environmental conditions.
To be added soon
Under Construction